![]() SALO, an 11 kDa protein, has no homology to proteins of any other organism apart from New World sand flies. Here, we identified SALO as the classical pathway complement inhibitor. Sand fly saliva was shown to inhibit the classical pathway of complement however, the molecular identity of the inhibitor remains unknown. Brandt Claudio Meneses Kolyvan Ferreira Lima Ricardo Nascimento Araújo Marcos Horácio Pereira Michalis Kotsyfakis Fabiano Oliveira Shaden Kamhawiīlood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Coutinho-Abreu Manoochehr Rasouli Elizabeth A. Pangburn Maha Abdeladhim Antonio Ferreira Mendes-Sousa Iliano V. SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis Importantly, due to its small size and specificity, SALO may offer a therapeutic alternative for complement classical pathway-mediated pathogenic effects in human diseases. In conclusion our data shows that SALO is a specific classical pathway complement inhibitor present in the saliva of Lu. Importantly, r SALO did not inhibit the alternative or the lectin pathway of complement. r SALO, however, did not inhibit the protease activity of C1s nor the enzymatic activity of factor Xa, uPA, thrombin, kallikrein, trypsin and plasmin. Both r SALO and SGH inhibited C4b deposition and cleavage of C4. longipalpis salivary gland homogenate (SGH)counterparts and anti-r SALO antibodies blocked the classical pathway complement activity of r SALO and SGH. r SALO anti-complement activity has the same chromatographic properties as the Lu. ![]() SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.įerreira, Viviana P Fazito Vale, Vladimir Pangburn, Michael K Abdeladhim, Maha Mendes-Sousa, Antonio Ferreira Coutinho-Abreu, Iliano V Rasouli, Manoochehr Brandt, Elizabeth A Meneses, Claudio Lima, Kolyvan Ferreira Nascimento Araújo, Ricardo Pereira, Marcos Horácio Kotsyfakis, Michalis Oliveira, Fabiano Kamhawi, Shaden Ribeiro, Jose M C Gontijo, Nelder F Collin, Nicolas Valenzuela, Jesus Gīlood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. ![]() ![]() Soome ja Eesti uute lastelaulude konkursist Salos, kus parimaks lauluks osutus Külli Marandi "Pesapuu" Rahvusvahelisest laste laulufestivalist 5.-8.juunil Salos, kus esikoha võitis 11. Kose laulupoiss võitis rahvusvahelise lauluvõistluse Salos / Riin Kivinurm ![]()
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